Dr. Saykin is Professor of Psychiatry and Radiology at Dartmouth Medical School and Adjunct Professor of Computer Science at Dartmouth College. He is the Director of the Neuropsychology Program and Brain Imaging Laboratory (BIL) at Dartmouth-Hitchcock Medical Center and New Hampshire Hospital. Dr. Saykin's research focuses on the use of state of the art neuroimaging to elucidate underlying mechanisms of memory dysfunction in neurological and psychiatric disorders and to assess the outcome of neuropharmacological and neurosurgical interventions. Dr. Saykin and colleagues have been awarded grants from the National Institutes of Health (NIA, NCI, NINDS) and National Science Foundation as well as from the Alzheimer's Association, Hitchcock Foundation, Ira DeCamp Foundation, National MS Society, NARSAD and Stanley Foundation among other sponsors. The BIL team has published extensively on CNS disorders including memory systems dysfunction in early Alzheimer's disease and MCI, schizophrenia, brain injury, MS and cancer treatment. Dr. Saykin is actively engaged in training the next generation of clinical neuroscientists to effectively employ cognitive and imaging methodologies in their research. He presently serves on the Brain Disorders and Clinical Neuroscience Study Section at NIH and the Board of Directors of the American Board of Clinical Neuropsychology.
Selected Publications:
Copenhaver, B., Rabin, L.A., Saykin, A.J., Roth, R.M., Wishart, H.A., Flashman, L.A., & Santulli, R. (in press). Reduced fornix and mammilary body volume in Alzheimer’s disease but not MCI or elderly with cognitive complaints. Psychiatry Research: Neuroimaging
McAllister, T.W., Flashman, L.A., McDonald B.C., Saykin A.J. (in press). Mechanisms of cognitive dysfunction after mild and moderate TBI (MTBI): Evidence from functional MRI and neurogenetics. Journal of Neurotrauma.
McHugh, T. L., Saykin, A. J., Wishart, H. A., Flashman, L. A., Cleavinger, H. B., Rabin, L. A., Mamourian, A. C., Shen, L. (in press). Hippocampal volume and shape analysis in an older adult population. The Clinical Neuropsychologist.
Roth, R.M., Koven, N.S., Flashman, L.A., Randolph, J.J., Pixley, H.S., Ricketts, S.M., Wishart, H.A., & Saykin, A.J. (in press). fMRI of executive control in adults with bipolar I disorder. NeuroReport.
Saykin, A. J., Wishart, H. A., Rabin, L. A., Santulli, R. B., Flashman, L. A., West, J. D., McHugh, T.L., Mamourian, A. C. (in press). Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI. Neurology.
Wishart, H. A., Saykin, A. J., Rabin, L. A., Santulli, R. B., Flashman, L. A., Guerin, S., Mamourian, A. C., Belloni, D., Rhodes, C. H., & McAllister, T. W. (in press). Increased prefrontal activation during working memory in cognitively intact APOE E4 carriers. American Journal of Psychiatry.
Wishart, H.A., Saykin, A.J., McAllister, T.W., Rabin, L.A., McDonald, B.C., Flashman, L.A., Roth, R.M., Mamourian, A.C., Tsongalis, G.J., Rhodes, C.H. (in press). Regional brain atrophy in cognitively intact adults with a single APOE e4 allele. Neurology.
Wang, P.J., Saykin, A.J., Flashman, L.A. Wishart, H.A. Rabin, L.A. Santulli, R.B.. McHugh, T.L McDonald, J.W. & Mamourian, A.C. (2005). Regionally specific atrophy of the corpus callosum in AD, MCI, and older adults with cognitive complaints. Neurobiology of Aging. Available on-line 11/05.
Ahles, T.A., Saykin A.J., Furstenberg, C.T., Cole, B.F., Mott, L.A., Titus-Ernstoff, L.T., Skalla, K.A., Bakitas, M. and Silberfarb, P.M. (2005). Quality of life of long-term survivors of breast cancer and lymphoma treated with standard-dose chemotherapy or local therapy. Journal of Clinical Oncology, 23(19):4399-405.
McAllister, T. W., Rhodes, C. H., Flashman, L. A., McDonald, B. C., Belloni, D., & Saykin, A. J. (2005). Effect of the Dopamine D2 Receptor T Allele on Response Latency After Mild Traumatic Brain Injury. American Journal of Psychiatry, 162:1749-1751.
Roth, R.M., Flashman, L.A., Saykin, A.J., McAllister, T.W., Vidaver, R. (2004). Apathy in schizophrenia: Reduced frontal volume and neuropsychological deficits. American Journal of Psychiatry, 161:157-159.
Roth, R.M., Wishart, H.A., Flashman, L.A., Riordan, H.J., Huey, L. & Saykin, A.J. (2004). Contribution of organization strategy to verbal learning and memory in adults with ADHD. Neuropsychology, 18(1), 78-84.
Wishart, H.A., Saykin, A.J., McDonald, B.C., Mamourian, A.C., Flashman, L.A., et al. (2004). Brain activation patterns associated with working memory in relapsing-remitting multiple sclerosis. Neurology. 62: 234-238.
Saykin AJ, Wishart HA, Rabin LA, Flashman LA, McHugh TL, Mamourian AC, Santulli RB (2004). Cholinergic enhancement of frontal lobe activity in Mild Cognitive Impairment. Brain, 127: 1574-1583.
Shen L, Ford J, Makedon F, Saykin AJ. (2004). A surface-based approach for classification of 3D neuroanatomic structures. Intelligent Data Analysis, An International Journal.
Roth RM, Wishart HA, Flashman LA, Riordan HJ, Huey L, Saykin AJ (2004). Contribution of organizational strategy to verbal learning and memory in adults with attention-deficit/hyperactivity disorder. Neuropsychology 18: 79-84.
Monarch ES, Saykin AJ, Flashman L.A. (2004). Neuropsychological impairment in borderline personality disorder. Psychiatric Clinics of North America, 27(1): 67-82.
Roth RM, Saykin AJ. (2004) Executive dysfunction in attention-deficit/hyperactivity disorder: cognitive and neuroimaging findings. Psychiatric Clinics of North America, 27(1): 83-96.
McAllister TW, Flashman LA, Sparling MB, Saykin AJ. (2004). Working memory deficits after mild traumatic brain injury: neuropharmacological mechanisms and prospects for catecholaminergic treatment. Brain Injury, 18(4): 331-350.
Likosky DS, Roth RM, Saykin AJ, Eskey CJ, Ross CS, O'Connor GT. Neurologic injury associated with CABG surgery: Outcomes, mechanisms, and opportunities for improvement. Heart Surgery Forum 2004;7(6):E650-E662.
APA Division 40 Task Force (2004). Official Position of the Division of Clinical Neuropsychology (APA Division 40) on the Role of Neuropsychologists in Clinical Use of fMRI: Approved by the Division 40 Executive Committee July 28, 2004. The Clinical Neuropsychologist, 18: 349-351.
McAllister TW, Ahles TA, Saykin AJ, Ferguson RJ, McDonald BC, Lewis LD, Flashman LA, Rhodes CH. Cognitive effects of cytotoxic cancer chemotherapy: predisposing risk factors and potential treatments. Current Psychiatry Reports, 6(5):364-71, 2004 Oct.